Usually avoid combinations; use it only under special circumstances. Either increases the level of the other by added drug effects. We comply with the HONcode standard for trustworthy health information. Do not take Neurontin or Gralise if you are allergic to gabapentin or any ingredients contained in this drug. Major Potential Hazard, High plausibility. Proc Natl Acad Sci U S A. Epub 2013 Apr 6. Some common combinations of gabapentin and benzodiazepines include: Because gabapentin can be used to help manage certain epilepsy disorders, it is commonly prescribed with other anticonvulsants, such as phenytoin, valproic acid, and phenobarbital. 2006 Jan;102(1):182-7. Understanding which medications interact with gabapentin and knowing how to take gabapentin safely will help you live a healthier life. (2021): United States National Library of Medicine "Toxnet. RxList does not provide medical advice, diagnosis or treatment. Dilantin (phenytoin)." (2018): "Product Information. 2023 Medicine.com All rights reserved. Umatilla, FL 32784. Gabapentin is not a narcotic. This document does not contain all possible interactions. Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Aclidinium. What Other Drugs Interact with Gabapentin. (n.d.). (2013). Gabapentin mirrors the effects of GABA calming excited neurons. (Wait two hours after taking aluminum and magnesium-containing antacids before taking gabapentin.). If you have any concerns or questions, be sure to call your healthcare provider or pharmacist right away. If patients have symptoms of suicidal ideation or behavior, treatment should be discontinued. Take with or without food. Gabapentin Disease Interactions There are 4 disease interactions with gabapentin. What should I know regarding pregnancy, nursing and administering Gabapentin to children or the elderly? There are 266 drugs known to interact with Curr Opin Pharmacol. Omni Laboratories Division, Warner Lambert Canada Inc. Dipentocaine Topical Cream Compounding Kit. "Product Information. Coming to a Cleveland Clinic location?Cole Eye entrance closingVisitation, mask requirements and COVID-19 information. Epub 2006 Sep 24. For this reason, talk to your healthcare provider as soon as you know you are pregnant. 2016 Feb;22(1 Epilepsy):132-56. doi: 10.1212/CON.0000000000000289. There are no controlled data in human pregnancy. If you are breastfeeding or planning to breastfeed, talk with your healthcare provider about breastfeeding or medication options. Therapy with AEDs should be administered cautiously in patients with depression or other psychiatric disorders. Potiga (ezogabine)." Taking gabapentin andValium(diazepam), a benzodiazepine may be necessary for managing seizure disorders in certain patients. The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. May 10, 2018. It is also used to relieve nerve pain following shingles (a painful rash due to herpes zoster infection) in adults . 9500 Euclid Avenue, Cleveland, Ohio 44195 |, (https://www.pfizermedicalinformation.com/en-us/patient/neurontin?section=full-pi), (https://www.rxlist.com/neurontin-drug.htm#description). Moderately clinically significant. If you forget to take a dose of gabapentin, take it as soon as you remember. This can be done by calling the toll-free number 1-888-233-2334 and must be done by patients themselves. Avoid combinations; the risk of the interaction outweighs the benefit. Why Doesn't the U.S. Have at-Home Tests for the Flu? Comments:-Breastfed infants should be monitored for drowsiness, adequate weight gain, and developmental milestones, especially when used in combination with other anticonvulsant or psychotropic drugs and in younger, exclusively breastfed infants.-Some authorities suggest discontinuing nursing or discontinuing use of this drug while breastfeeding due to the potential for serious adverse reactions in the breastfed infant. Selected from data included with permission and copyrighted by First Databank, Inc. . 2005 - 2023 WebMD LLC. 2005 Nov 4;280(44):37246-56. For clinically significant or persistent symptoms, a dosage reduction or treatment withdrawal should be considered. (1986): 830-9. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Highly clinically significant. See additional information. Also, do not split sustained-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Avoid life-threatening adverse drug events & improve clinical decision support. Tolerance as well as physical and psychological dependence can develop, particularly after prolonged use of excessive dosages, and abrupt cessation and/or a reduction in dosage may precipitate withdrawal symptoms. Gabapentin is a prescription medication known as a gamma aminobutyric acid (GABA) analogue. Gabapentin is removed by hemodialysis and should be administered after dialysis. Dose gradually to 1800 mg/day orally; take once a day with evening meal. The absence of an interaction does not necessarily mean no interactions exist. Brand names of gabapentin include Horizant, Gralise and Neurontin. Certain medicines for stomach problems. It's not classified as a controlled substance in most states. While its common to co-prescribe opioids and gabapentin for nerve pain, the combination has anincreased riskfor sedation, respiratory depression, and abuse. Moderately clinically significant. From the limited amount of data in human pregnancy, it is not possible to inform an associated increased risk of congenital malformations because epilepsy itself and the presence of concomitant antiepileptic medicinal products have their own risks. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. Ambien (zolpidem)." sanofi-aventis Eye problems: unusual eye movements, double vision. [, Sills GJ: The mechanisms of action of gabapentin and pregabalin. Lancet 342 WebMD does not provide medical advice, diagnosis or treatment. Gabapentin can interact with some over-the-counter (OTC) medications and supplements. Privacy Policy, Gabapentin During Pregnancy & Breastfeeding. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Anaphylaxis and angioedema reported after first dose or at any time during treatment; instruct patients to discontinue therapy and seek medical care should they experience signs or symptoms of anaphylaxis or angioedema. Lyricaand gabapentin are not typically recommended to be taken together because they both mimic the effects of the same chemical in the brain. Applicable conditions: Drug Abuse/Dependence Anxiolytic, sedative, and hypnotic agents have the potential to cause dependence and abuse. [, Bockbrader HN, Wesche D, Miller R, Chapel S, Janiczek N, Burger P: A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Some people may also experience impairment in thinking and judgment. "Product Information. Gralise (gabapentin)." These medications are not usually taken together. The risk of suicidal thoughts and behavior should be carefully assessed against the risk of untreated illness, bearing in mind that epilepsy and many other conditions for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior. Eisai Inc 2023 The Recovery Village Drug and Alcohol Rehab All Rights Reserved. GlaxoSmithKline Prac Pain Mgt, (https://www.practicalpainmanagement.com/treatments/pharmacological/non-opioids/special-report-abuse-potential-gabapentin-pregabalin). Gabapentin is available under the following different brand names: Reducing the dose, discontinuing the drug, or substituting an alternative medication should be done gradually over a minimum of 1 week or longer. Available for Android and iOS devices. Gabapentin is an anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Review our medical disclaimer. GABAPENTIN/ALUMINUM . Neurontin (gabapentin)." Never take more than one dose in an attempt to catch up. Cavallaro R, Regazzetti MG, Covelli G, Smeraldi E "Tolerance and withdrawal with zolpidem." Pooled analyses of 199 placebo-controlled clinical studies involving the use of 11 different AEDs across multiple indications in either monotherapy or adjunctive therapy for a median treatment duration of 12 weeks (up to a maximum of 24 weeks) showed that patients receiving AEDs had approximately twice the risk of suicidal thinking or behavior compared to patients receiving placebo. Sabril (vigabatrin)." Accessed August 3, 2019. Curr Top Med Chem. The most common side effects of gabapentin are: Dizziness Sleepiness Ataxia Fatigue Drowsiness Fluid retention (edema) Hostility Nausea Vomiting Difficulty speaking Jerky movements Unusual eye movements Double vision Tremors Memory loss Unsteadiness Other adverse effects and serious side effects associated with gabapentin include: Weight gain Therapy with gabapentin should be administered cautiously in patients with impaired renal function. 2018 Oct;94(4):1155-1163. doi: 10.1124/mol.118.112953. Applicable conditions: Depression, Psychosis. Gabapentin is available in both branded and generic forms. Gabapentin withdrawal symptoms have been reported since the drug was approved. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Gabapentin is used to help control partial seizures (convulsions) in the treatment of epilepsy. Swallow tablets whole with a full glass of water. (2001): Gericke CA, Ludolph AC "Chronic abuse of zolpidem." Serious breathing problems can happen if you take gabapentin with drugs that cause severe sleepiness or decreased awareness. These medications may cause some risk when taken together. Are pregnant, trying to become pregnant or are breastfeeding. Placidyl (ethchlorvynol)." Select a condition to view a list of medication options. Ages 3-12 years: Risk of neuropsychiatric adverse events, including emotional lability, hostility, thought disorders, and hyperkinesia. There are 4 disease interactions with gabapentin which include: drug dependence renal dysfunction suicidal tendency hemodialysis Report options Share by QR Code Email this report to a friend, doctor, or patient Ask questions, find answers More about gabapentin gabapentin consumer information Check interactions Compare alternatives Pricing & coupons U.S. Patent US4960931, issued May, 1978. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Gabapentin is called a central nervous system (CNS)depressantbecause it slows down some of the functions and processes of the brain. Please contact your doctor or pharmacist. Maintenance: Subsequently titrate as needed up to 600 mg orally every 8 hours; doses greater than 1800 mg/day have demonstrated no additional benefit. Aquachloral Supprettes (chloral hydrate)." Do not use more than the recommended dose of gabapentin, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Improve clinical decision support with information on. Epilepsia. Common medications that may interact with gabapentin include: antacids, such as those containing aluminum and magnesium anti-anxiety medications, such as diazepam, lorazepam, and flunitrazepam antidepressants, such as amitriptyline, citalopram, fluoxetine, paroxetine antihistamines, such as chlorpheniramine, promethazine In rats, an increased incidence of hydroureter and/or hydronephrosis have been observed in offspring at all doses, the lowest dose being similar to the maximum recommended human dose on a mg/m2 basis. Moderate Interactions. These include opioids, benzodiazepines, and alcohol. These medications may cause some risk when taken together. Moderate Potential Hazard, Moderate plausibility. Accessed August 4, 2019. Talk to your doctor or pharmacist if you have any questions or concerns. Use gabapentin with caution if benefits outweigh risks in pregnancy. When taking these antacids, such as Maalox, it is recommended to take gabapentin at least two hours after taking the antacid. Some mixtures of medications can lead to serious and even fatal consequences. Pfizer U.S. Pharmaceuticals Group Neurontin (gabapentin)." Sonata (zaleplon)." Gabapentin (Neurontin) can interact with medications and substances that make you sleepy. [, Maneuf YP, Luo ZD, Lee K: alpha2delta and the mechanism of action of gabapentin in the treatment of pain. It is safe to take gabapentin and other medications that have been prescribed or ordered by your doctor. Check with your physician for additional information about side effects. Sorry, we have no data available. Moderately clinically significant. dizziness, drowsiness, slurred speech, lethargy, loss of consciousness) and gastrointestinal symptoms such as diarrhea.18,17 Management of overdose should involve symptomatic and supportive treatment. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Jonathan Strum graduated from the University of Nebraska Omaha with a Bachelor's in Communication in 2017 and has been writing professionally ever since. Gabapentin possesses CNS depressant activity that may be potentiated by co-administration with alcohol. The phase IV clinical study analyzes what interactions people who take Fluoxetine and Gabapentin have. Usually avoid combinations; use it only under special circumstances. Until more data becomes available, the developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for this drug and any potential adverse effects on the breastfed infant from this drug or from the underlying maternal condition.